Search results for "Multicomponent solid dispersion Microparticles Irinotecan Inulin Spray-drying"

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Multicomponent solid dispersion as a formulation strategy to improve drug permeation: A case study on the anti-colorectal cancer irinotecan

2019

Abstract Multicomponent solid dispersions (MSD)s are frequently proposed as efficient drug delivery systems to improve drug solubility and bioavailability. In this study, the effects of specific excipients, such as mannitol, inulin, poly(methyl methacrylate-co-methacrylic)acid (PMMA) and cellulose acetate phthalate (CAP) have been tested to potentially improve irinotecan (IRN) permeation in the intestinal tract with the intention to protect the drug from the gastric environment. MSDs were formulated as microparticles by Spray-Drying technique. Raw materials and microparticles have been characterized by FTIR analysis to determine hydrogen bonding. SEM images were recorded to investigate morp…

ChromatographyPharmaceutical Science02 engineering and technologyPermeation021001 nanoscience & nanotechnology030226 pharmacology & pharmacyBioavailabilityMulticomponent solid dispersion Microparticles Irinotecan Inulin Spray-drying03 medical and health scienceschemistry.chemical_compound0302 clinical medicineCellulose acetate phthalatechemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliveryDissolution testingParticle sizeSolubility0210 nano-technologyDissolutionJournal of Drug Delivery Science and Technology

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